ChromGate is the perfect solution for your
data managementneeds. It is suitable for
control of all
instruments. With the addition
of a KNAUER interface module, you can
also easily integrate
other instruments. Even in its basic
ChromGate offers a diversity of functions that satisfy almost
every need, including an excellent array of tools for the precise
of your data or the possibility to automatically perform
depending on instruments status like
run or sending an e-mail message. ChromGate's
user friendliness is in large part due to its simple user
and the so-called "wizard"
that assist in the programming of
basic methods and sequence parameters.
can be automatically carried out by
simply incorporating these into a program sequence – from calibration to sample
analysis and data evaluation, to complete system control. Calibration of
samples is effortless with ChromGate. You can control every step and also
edit any parameter as necessary.
Whether for single analyses or sequence runs, ChromGate gives you the option to construct custom reports or to just take prewritten
The best solution for large and small laboratories
ChromGate can also be customized with
available options to meet all of your needs. For example, with the PDA
(photodiode array) option you can take full advantage of the possibility for
2-D and 3-D Chromatograms, peak purity analysis, or spectrum search in a
Other available options include a molecular mass
determination function for use in size exclusion chromatography (SEC) or gel
permeation chromatography (GPC) with various calibration methods and a System
Suitability Test for system validation where the performance parameters of the
HPLC system (retention times, as well as flow rate consistency, peak symmetry, efficiency,
and many more) can be regularly checked.
Thanks to its straightforward expandability, ChromGate
delivers the necessary performance for large networked laboratories yet is at
the same time simple enough to also be used effectively in small laboratories.
The logical Client/Server architecture allows for ChromGate to be used from every computer in the network. It is possible to
process data in the office as well as to control the HPLC system over the
Instrument Server PC in the laboratory. Users and groups as well as access
rights can be easily modified from the Windows™ domain controller.
ChromGate can be used in a large network
as stand-alone which can control
different systems from single workstation
ChromGate sets the standard for
Chromatography Data Systems
FDA 21 CFR Part 11
ChromGate provides the highest available level
of data security and GLP compliance. It fully implements the guidelines specified
by FDA 21 CFR Part 11 for the storage and protection of electronic archived
data and electronic signatures.
Other features include password-protected login with
different access rights on operating system level (Windows™ NT/2000/XP),
protection from in advertent data deletion, as well as the possibility for
complete data back-tracking. The method and the hardware configuration are
saved with every data record so that all relevant information is accessible at
any time. More features include an activity log and the Audit Trail Option for
methods, sequences, and chromatograms.
An Operation Qualification
procedure for KNAUER pumps and detectors is integrated into ChromGate. A wizard guides you through each step to qualification of the
individual instrument module and simplifies its validation. The analysis is
then made automatically by the software and documented by a final test report.
Has your HPLC system ever run dry? ChromGate does the thinking for you and calculates the expected eluent consumption with the Solvent Control feature for the
Smartline instruments. You can determine by what amount of solvent remainder you
want to be warned and when the pumps should be shut off.
Instrument control at your finger tips
Direct Control Mode
Particularly noteworthy is the Instrument Status window in
which essential control functions and current status information are always in
view. The most important instrument parameters such as flow rate or detector
wavelength can be adjusted from here with a single mouse click, even while in
the middle of a run – ideal for method development.
32-bit Chromatography Data Management System with
Client/Server technology for instrument control, acquisition of data, data
processing, and report creation.
From a stand-alone workstation up to
a complete enterprise-wide Client/Server solution.
Stand-Alone: One PC carries out all tasks from system control to data
storage, to data analysis and reporting.
Client/Server: Control and data recording are done from a server on which
the HPLC system(s) is connected. The system can be controlled and the data can
be processed directly on the instrument Server PC or on any other client PC in
the network and even over the internet.
Storage of all measurement data on a central server is
possible. In case of temporary interruptions in service on the IT network, the
data from running measurements is kept in the Instrument Server PC buffer until
these can be transferred to the central server accurately.
Microsoft Windows™ NT 4.0, Windows™
2000 and Windows™ XP Pro, for stand-alone systems as well as Client/Server.
Windows™ 98 for stand-alone systems and clients.
Note: Windows™ 98 does not provide for password security and
hence does not satisfy FDA 21 CFR Part 11.
1 x RS-232 per instrument (up to 2
Knauer Net instruments per serial interface), DAD either by Ethernet or PCI
instruments through interface module.
PC Hardware Requirements
Min. Pentium III 500 MHz; 256 MB RAM (depending on operating
system), additional RAM required when more than one HPLC system is connected;
min. 300 MB hard drive space.
Data Import & Export
ASCII, ANDI standard, and OLE (object linking and embedding)
for import into documents of other applications; ODBC for exchange with Windows™
– based LIMS or databases.
Multiple chromatogram view: zoom, print, cut, paste, copy.
Mathematical operations such as align, stretch, move, or stacking of
chromatograms. Modification of line color, type, and
thickness, Full control of annotations for all peak parameters (e.g. angle,
font style, size, and color).
Real time analysis of peaks,
automatic or manual integration and baseline correction.
Security and GLP
System integrity test of the software
by validation tool.
FDA 21 CFR Part 11 conforming (except under Windows TM 98), control of user
privileges, various access levels, method, sequence, and data audit trails,
electronic signature. Method parameters are saved in original data file and are
protected against manipulation through checksums. Activity log files for
Instrument status display and Direct Control Mode are also
possible while acquiring data, "wizard" simplify programming of
methods and sequences. Smart Sequence TM feature allows for automatic execution
of pre-programmed functions such as Reinject, stop,
Interactive peak selection by mouse. Calibration curve
fitting. Removal of outliers. Automatic
peak naming and ordering.
Custom reports with an extensive set of options. Pre-defined templates.
Solvent level controller for
Smartline instruments. Operation Qualification for
detectors and pumps.
KNAUER offers brands-name PCs on which ChromGate has
been completely preinstalled and tested. Our PCs meet all ChromGate
requirements and are at the current state of the art when delivered.